منابع مشابه
Hypogonadism and aging
The Massachusetts Male Aging Study [1] shows that male hormones decrease with aging. This is due to some testicular and hypothalamic-pituitary defects. Impaired hypothalamic secretory reserve, resulting in a reduced and chaotic secretion of GnRH, reduced pituitary response to GnRH, resulting in an increased but irregular LH pulse frequency [2] With aging, there is a 1.3% increase of sex hormone...
متن کاملLong-term suppression of Leydig cell steroidogenesis prevents Leydig cell aging.
Male aging is accompanied by reduced testosterone production by the Leydig cells, the testosterone-producing cells of the testis. The mechanism by which this occurs is unknown. Based on the observations that reactive oxygen is capable of damaging components of the steroidogenic pathway and that reactive oxygen is produced during steroidogenesis itself, we hypothesized that long-term suppression...
متن کاملStem cell therapy for the treatment of Leydig cell dysfunction in primary hypogonadism
The production of testosterone occurs within the Leydig cells of the testes. When production fails at this level from either congenital, acquired, or systemic disorders, the result is primary hypogonadism. While numerous testosterone formulations have been developed, none are yet fully capable of replicating the physiological patterns of testosterone secretion. Multiple stem cell therapies to r...
متن کاملAre Leydig cell steroidogenic enzymes differentially regulated with aging?
Previous studies have shown that the ability of Brown Norway rat Leydig cells to produce testosterone declines significantly with age. To address the possible mechanism(s) by which aging Leydig cells lose steroidogenic function, we determined the effect of age on the steady-state levels of the mRNAs for the steroidogenic enzymes P450 cholesterol side-chain cleavage (P450scc), delta 5-3 beta-hyd...
متن کاملIn congenital hypogonadotropic hypogonadism (CHH), the postnatal subcutaneous infusion of gonadotropins (CSIG) induces Leydig and Sertoli cell development and activation
In normal male infants, the postnatal surge in pulsatile gonadotropin secretion is associated with a rapid expansion of Leydig and Sertoli cell populations with concommittant surges in testosterone, inhibin and AMH production. Boys with CHH are almost invariably faced with azoospermia and infertility in adult life, likely to be due to deficient FSH and proliferation of immature Sertoli cells be...
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ژورنال
عنوان ژورنال: Experimental Gerontology
سال: 2015
ISSN: 0531-5565
DOI: 10.1016/j.exger.2015.02.014